See bladder cancer in a different light
Blue Light Cystoscopy
with
Cysview® improves detection
of non-muscle invasive
bladder cancer1,2
See bladder cancer in a different light
Blue Light Cystoscopy with Cysview® improves detection of non-muscle invasive bladder cancer1,2
What is Cysview?
FDA-approved Cysview makes non-muscle invasive bladder cancer (NMIBC) tumors glow bright pink under blue light during Blue Light Cystoscopy (BLC®).3
Cysview solution is placed into the bladder of a bladder cancer patient via a catheter one hour prior to BLC.3 During BLC, Cysview then allows urologists to remove cancer more completely than with standard White Light Cystoscopy (WLC) alone, because BLC with Cysview makes tumors more visible.1,2
Indication: Cysview is an optical imaging agent indicated for use in the cystoscopic detection of carcinoma of the bladder, including carcinoma in situ (CIS), among patients suspected or known to have lesion(s) on the basis of a prior cystoscopy, or in patients undergoing surveillance cystoscopy for carcinoma of the bladder. Cysview is used with the KARL STORZ D-Light C Photodynamic Diagnostic (PDD) system to perform BLC as an adjunct to WLC.3
Who is Cysview® for?
Cysview is for use in people suspected of having, or are known to have, bladder cancer or those undergoing bladder cancer surveillance.3
It should be used during initial or repeat transurethral resection of bladder tumor (TURBT)4 and in surveillance cystoscopies.5
Blue Light Cystoscopy (BLC®) with Cysview® improves non-muscle invasive bladder cancer (NMIBC) tumor detection1,2
What evidence supports Cysview®?
Two different prospective, multicenter clinical studies looked into the effectiveness of BLC with Cysview versus standard White Light Cystoscopy (WLC) alone in detecting bladder cancer in over 300 patients with known or suspected bladder cancer.
They showed that BLC with Cysview improved tumor detection during surgery and in follow-ups:1–3
Study 1:2,3
About the study
A prospective, comparative, within-patient controlled, multicenter, phase III study in the detection of Ta/T1 NMIBC in patients who had previously undergone a cystoscopy and had suspicion of or confirmed NMIBC. (n=286)
Results
During surgery, 16% of patients had additional Ta/T1 tumors only found with BLC with Cysview.
had additional Ta/T1 tumors only found with BLC with Cysview, during surgery2,3
Study 2:1,3
About the study
A prospective, comparative, within-patient controlled, multicenter, phase III study in the detection of bladder cancer during surveillance. Patients with suspected recurrence at surveillance were sent to the operating room. (n=63)
Results
At follow-up, only BLC with Cysview detected 21% of patients with recurrence
During surgery, 35% of patients with CIS tumors were only found with BLC with Cysview
Study 2:1,3
About the study
A prospective, comparative, within-patient controlled, multicenter, phase III study in the detection of bladder cancer during surveillance. Patients with suspected recurrence at surveillance were sent to the operating room. (n=63)
Results
- At follow-up, only BLC with Cysview detected 21% of patients with recurrence
- During surgery, 35% of patients with CIS tumors were only found with BLC with Cysview
Could Blue Light Cystoscopy (BLC®) with Cysview® be for me?
BLC with Cysview should be considered for patients that are:
At initial transurethral resection of bladder tumor (TURBT) on suspicion of non-muscle invasive bladder cancer (NMIBC)4
- Having repeat TURBT4
Being checked to assess response to Bacillus Calmette-Guérin (BCG) therapy six weeks after completion4
- Undergoing surveillance4,5
- Prior to intravesical therapy when residual disease is suspected, i.e., patient has not previously had BLC with Cysview5
- With positive cytology and negative White Light Cystoscopy (WLC)4
Cysview may not detect all bladder tumors and is not a replacement for random biopsies
Where is Blue Light Cystoscopy (BLC®)
with Cysview® available?
Cysview is available in many locations throughout the US, with more locations being added regularly.
If you’d like to know where Blue Light Cystoscopy
is available near you, Please reach out.
Two types of cystoscopy
White Light Cystoscopy (WLC)
In a standard cystoscopy procedure, the light used is a regular white light – the type used to light a room. White light helps the urologist visually assess the general health of the bladder and find easily visible irregularities to be further evaluated.6
Blue Light Cystoscopy (BLC®)
See the difference
Bladder images under white and blue light*
Standard WLC
BLC® with Cysview®
*Side-by-side images are the same area of the bladder in white and blue light.
Cysview may not detect all malignant lesions.
Example Patient Journey
Safety information
Any procedure may have some risks. You should consult your urologist regarding the risks and benefits of this procedure.
The most common adverse reactions reported in patients who received Cysview were:3
- Bladder spasm
- Dysuria
- Hematuria
- Bladder pain
The following adverse reactions have been voluntarily reported during post-approval use of Cysview. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure:3
- Anaphylactoid shock
- Hypersensitivity reactions
- Bladder pain
- Cystitis
- Abnormal urinalysis
References
1. Daneshmand S, Patel S, Lotan Y, et al. Efficacy and Safety of Blue Light Flexible Cystoscopy with Hexaminolevulinate in the Surveillance of Bladder Cancer: A Phase III, Comparative, Multicenter Study. J Urol. 2018;199(5):1158–1165. 2. Stenzl A, Burger M, Fradet Y, et al. Hexaminolevulinate Guided Fluorescence Cystoscopy Reduces Recurrence in Patients with Nonmuscle Invasive Bladder Cancer. J Urol. 2010;184(5):1907–1913. 3. Cysview [prescribing information]. 2019:1–4. 4. Daneshmand S, Schuckman AK, Bochner BH, et al. Hexaminolevulinate Blue-Light Cystoscopy in Non-Muscle-Invasive Bladder Cancer: Review of the Clinical Evidence and Consensus Statement on Appropriate Use in the USA. Nat Rev Urol. 2014;11(10):589–596. 5. Lotan Y, Bivalacqua TJ, Downs T, et al. Blue Light Flexible Cystoscopy with Hexaminolevulinate in Non-Muscle-Invasive Bladder Cancer: Review of the Clinical Evidence and Consensus Statement on Optimal Use in the USA – Update 2018. Nat Rev Urol. 2019;16(6):377–386. 6. Urology Group of Florida. What is Blue Light Cystoscopy? Available at: https://www.urologygroupfl.com/post/what-is-blue-light-cystoscopy. Accessed March 2024.
